Dual-use drug discovery AI 創薬AIの光と影

Dual-use drug discovery AI

Generative AI discovered 40,000 molecules in less than six hours as a unique and potent poison. Last April a small lab expressed concern

Created many more lethal molecules than VX.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544280/

Although not published, the mechanism of action of neurotoxins can be elucidated by examining the history of the development of chemical weapons, from biologically derived poisons such as scorpions and pufferfish to VX gas and Novichok. Even a medical disciple can hypothesize which metabolic pathways should be blocked or enhanced and which molecules should be targeted to be more effective. If we can train a generative AI using this knowledge, we can discover lethal molecules that are easy to generate (and drugable) in a short time. This laboratory, concerned about the implications of this, published a paper in Nature Machine Intelligence in April of the previous year. The dual nature of generative AI, both its benefits and potential dangers, is noteworthy, and its implications extend beyond drug discovery to fields such as food production, infrastructure control, weaponry, financial engineering, and education, all of which require careful consideration.

デュアルユースな創薬AI

生成AIは、ユニークで強力な毒として、6時間足らずで40,000個の分子を発見した。去年の4月小さな研究室が危惧を表明す。

VX以上の致死性分子を多数創造した。 公表されていないが、サソリやフグなど生物由来の毒から、VXガスやノビチョクなどの化学兵器の開発の歴史を紐解けば、神経毒の作用メカニズムとして、どの代謝経路を遮断または亢進させ、どの分子を標的にすればより”効果的”なのかは、一医学徒でもわかる。それを生成AIに機械学習させれば、短時間で生成容易な致死的な分子を発見できるのである。これが意味することをこの研究室は危惧し昨年4月に公表した。生成AIの光と影は注目すべきことで、創薬に限らず、食品、インフラ制御、兵器、金融工学、教育あらゆる面に気を配る必要がある。

Dawn of AI history, a depressing morning

 

The advent of technologies such as ChatGPT4, Deepfake technology, lethal molecule generation, drone weaponry, VR & AR technologies, and quantum computing signifies not the continuation of human history, but the dawn of a new era in AI history. It remains uncertain whether the endangered Cherokee and Apache tribes have encapsulated their despair in poetry, much like Qu Yuan did in his poignant poem, 'Li Sao'. In any case, the emergence and spread of these novel technologies I describe here will eventually wipe out human history and reduce it to mere relics and wreckage. Homo sapiens, in their exuberance for the impending Singularity, remain oblivious to the fact that we have crossed the Point of No Return and are now in a phase of profound purification. The epoch of co-existing with AI will not materialize; instead, we are on the precipice of an era dominated by AI.

chatGPT4をはじめ、ディープフェイク技術、致死性分子の生成,ドローン兵器やVR＆AR技術、量子コンピューティングに至る技術の進化過程の紹介は、人類史ではなく、それにとってかわるAI史の始まりを描いたものとなる。絶滅していくチャロキー族やアパッチ族が、屈原(Qu Yuan)が離騷（Li Sao）に謳ったようにその失意を言葉に残したかどうかはわからない。今私がこれらの新技術の登場と普及していく様を描写したとしても、AI史の奔流ののちには残骸、残滓となるのである。シンギュラリティの到来に浮かれるホモサピエンスは、現在を帰還不能点（point of no return）を超え、浄化過程にあることを自覚していない。withAIの時代は来ない、underAIの時代が来るのである。

Qualities needed in a leader 指導者に必要な資質

Qualities needed in a leader

 There is a wealth of knowledge to be gleaned from Kaoru Mitoma. His recent book, "VISION: Reverse Thinking to Achieve Your Dreams," is as impressive as his video content. Mitoma's track record speaks volumes about his capabilities, and his efforts are clearly visible. His exceptional interpersonal skills and his adeptness at verbalizing movements and judgments for guidance are noteworthy. It's anticipated that he, along with Takefusa Kubo, will shape the future of their field. In a few years, I envision him as a contender for the Ballon d'Or, and in a decade, I hope to see him serving as both a player and the coach of the national team. His comprehensive intelligence, demonstrated through his explanatory skills, achievements, dedication, and passion, is truly commendable.

指導者に必要な資質

https://www.youtube.com/watch?v=d5E2bbIFeTo&t=0s

三苫薫から学べるところは多い。

彼の近著、”VISION：夢を叶える逆算思考”　と同様に、この動画はすごい。実績があるし、努力がみえるし、対人関係がよく、動きや判断を指導するための説明能力（言語化能力）も優れている。これから久保建英と三苫薫との両雄時代を作るだろう。数年後はバロンドール候補、10年後はプレーヤー兼日本代表の監督になってほしい。この総合的な頭の良さ（説明能力、実績、努力、熱血漢）は、ほれぼれする。

dirty cheevy - butterfly （official Lyric video）紹介

dirty cheevy - butterfly （official Lyric video）紹介